Motif ID: STAT5{A,B}.p2

Z-value: 1.340


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B



Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_22305570 2.327 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr19_+_49361054 2.216 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr14_+_23700261 1.990 NM_006084
IRF9
interferon regulatory factor 9
chr6_+_139136349 1.975 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr14_-_19951417 1.975 NM_007110
TEP1
telomerase-associated protein 1
chr19_+_49309350 1.939 NM_013362
ZNF225
zinc finger protein 225
chr17_+_36515166 1.810 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr19_-_49552638 1.779 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_49198916 1.778 NM_006300
ZNF230
zinc finger protein 230
chr20_-_18425811 1.726 NM_006606
RBBP9
retinoblastoma binding protein 9
chr19_+_49290319 1.664 NM_013398
ZNF224
zinc finger protein 224
chr2_-_142605010 1.654 LRP1B
low density lipoprotein receptor-related protein 1B
chr9_+_103200939 1.592 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr19_-_51058177 1.568 NM_004819
SYMPK
symplekin
chr2_+_95194903 1.563 NM_001017396
NM_021088
ZNF2

zinc finger protein 2

chr16_-_69030421 1.558 NM_006927
ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr19_-_49131250 1.555 NM_003425
ZNF45
zinc finger protein 45
chr2_+_95195260 1.505 ZNF2
zinc finger protein 2
chr2_-_85435074 1.484 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr19_-_62680703 1.481 NM_001024596
NM_001144068
ZNF772

zinc finger protein 772

chr20_-_25625173 1.411 NM_015655
ZNF337
zinc finger protein 337
chr6_+_28156460 1.381 NM_003447
ZNF165
zinc finger protein 165
chr17_-_18526296 1.369 NM_001145045
ZNF286B
zinc finger protein 286B
chr19_+_42400908 1.361 ZNF383
zinc finger protein 383
chr17_-_17435631 1.355 NM_148172
PEMT
phosphatidylethanolamine N-methyltransferase
chr19_+_49221333 1.295 NM_001129996
NM_013360
ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_+_49268106 1.235 NM_001037813
ZNF284
zinc finger protein 284
chr7_-_93471463 1.205 NM_005868
BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr1_+_40769877 1.194 ZNF684
zinc finger protein 684
chr18_-_45241014 1.187 NM_017653
DYM
dymeclin
chr19_+_49408523 1.177 NM_182490
ZNF227
zinc finger protein 227
chr16_+_10945815 1.161 NM_015226
CLEC16A
C-type lectin domain family 16, member A
chr6_-_27548438 1.156 NM_007149
ZNF184
zinc finger protein 184
chr19_+_62638474 1.128 NM_001023561
ZNF749
zinc finger protein 749
chr11_-_82674546 1.127 CCDC90B
coiled-coil domain containing 90B
chr2_+_43854681 1.117 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr14_-_67232172 1.066 NM_016026
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr19_+_45194782 0.991 NM_178544
ZNF546
zinc finger protein 546
chr2_-_142605739 0.975 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr11_+_65024889 0.974 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr2_-_27739947 0.969 NM_014860
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr10_-_121345968 0.929 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr2_+_219283751 0.916 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr20_-_42713663 0.914 ADA
adenosine deaminase
chr18_+_41938295 0.892 NM_138443
HAUS1
HAUS augmin-like complex, subunit 1
chr2_+_63669596 0.888 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr11_+_71317736 0.873 RNF121
ring finger protein 121
chr1_-_151788341 0.870 NM_002960
S100A3
S100 calcium binding protein A3
chr2_+_69974581 0.835 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr16_+_52295545 0.809 FTO
fat mass and obesity associated
chr9_-_103200697 0.793 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr6_-_30766621 0.780 NM_007243
NRM
nurim (nuclear envelope membrane protein)
chr17_-_44847214 0.764 PHB
prohibitin
chr1_+_40769819 0.751 NM_152373
ZNF684
zinc finger protein 684
chr5_-_137542198 0.733 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr20_-_42713778 0.731 NM_000022
ADA
adenosine deaminase
chr11_-_82675024 0.724 NM_021825
CCDC90B
coiled-coil domain containing 90B
chr6_+_20642665 0.712 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr19_-_41849558 0.698 NM_153257
ZNF461
zinc finger protein 461
chr11_+_36572615 0.687 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr19_+_42033564 0.665 ZNF345
zinc finger protein 345
chr19_+_49337548 0.651 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chrX_+_48219344 0.644 NM_012280
NM_177439
FTSJ1

FtsJ homolog 1 (E. coli)

chr17_+_36636404 0.643 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr5_+_178219519 0.626 NM_058230
ZNF354B
zinc finger protein 354B
chr19_-_3712621 0.626 NM_004886
APBA3
amyloid beta (A4) precursor protein-binding, family A, member 3
chr14_+_23175383 0.624 NM_005794
NM_182908
DHRS2

dehydrogenase/reductase (SDR family) member 2

chr11_-_125278296 0.620 NM_031307
PUS3
pseudouridylate synthase 3
chr8_+_27687821 0.616 NM_001017420
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr14_-_69953433 0.615 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr19_+_49337568 0.612 ZNF234
zinc finger protein 234
chr17_-_36528113 0.610 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr4_-_77176163 0.604 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr10_-_131799051 0.599 LOC387723
hypothetical LOC387723
chr17_-_44847215 0.591 NM_002634
PHB
prohibitin
chr2_-_63669265 0.576 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chr2_-_63669022 0.568 WDPCP
WD repeat containing planar cell polarity effector
chr19_+_42033106 0.562 NM_003419
ZNF345
zinc finger protein 345
chr1_+_203503214 0.557 TMCC2
transmembrane and coiled-coil domain family 2
chr6_-_46728188 0.556 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr16_-_20246309 0.543 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr8_-_66708954 0.543 ARMC1
armadillo repeat containing 1
chr8_-_66708948 0.534 ARMC1
armadillo repeat containing 1
chr20_+_12937616 0.521 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr8_-_109330116 0.520 NM_001568
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr4_+_9094611 0.513 NM_001040071
LOC650293
seven transmembrane helix receptor
chr7_-_132417374 0.507 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr9_-_133944877 0.506 MED27
mediator complex subunit 27
chr2_+_219283928 0.498 TTLL4
tubulin tyrosine ligase-like family, member 4
chr3_+_171422940 0.491 PRKCI
protein kinase C, iota
chr17_-_77616803 0.490 DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chr1_-_153379344 0.489 NM_018973
NM_153741
DPM3

dolichyl-phosphate mannosyltransferase polypeptide 3

chr1_-_206125877 0.479


chr19_+_62950001 0.472 ZNF776
zinc finger protein 776
chr8_-_110415448 0.467 NM_032869
NUDCD1
NudC domain containing 1
chr19_-_41711009 0.456 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr19_+_40900965 0.453 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr19_-_49309102 0.451 LOC100379224
hypothetical LOC100379224
chr19_-_41672176 0.449 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr8_-_109330101 0.446 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_+_218698242 0.445 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr4_-_89299034 0.442 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr5_+_137542315 0.436 NM_005733
KIF20A
kinesin family member 20A
chr2_-_230792844 0.434 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr19_+_63022879 0.427 LOC100293516
zinc finger protein
chr18_-_42815965 0.423 NM_016427
TCEB3B
transcription elongation factor B polypeptide 3B (elongin A2)
chr17_-_77616953 0.423 DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chr8_-_66708967 0.419 NM_018120
ARMC1
armadillo repeat containing 1
chr14_-_76958984 0.414 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr20_+_35406497 0.413 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr19_+_49248003 0.408 NM_013361
ZNF223
zinc finger protein 223
chr15_+_20384835 0.407 NM_001102610
NM_052903
TUBGCP5

tubulin, gamma complex associated protein 5

chr3_+_199161446 0.406 NM_000996
RPL35A
ribosomal protein L35a
chr17_+_36665161 0.402 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr19_+_62949972 0.399 NM_173632
ZNF776
zinc finger protein 776
chr19_+_39587108 0.395 NM_032346
PDCD2L
programmed cell death 2-like
chr2_+_27740254 0.394 SLC4A1AP
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr2_-_63669085 0.390 WDPCP
WD repeat containing planar cell polarity effector
chr6_-_45453552 0.390 NM_003599
NM_181356
SUPT3H

suppressor of Ty 3 homolog (S. cerevisiae)

chr6_-_32892705 0.385 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr17_-_77616968 0.384 NM_022156
DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chr5_+_140454382 0.384 NM_018936
PCDHB2
protocadherin beta 2
chr19_+_63053031 0.380 NM_032828
ZNF587
zinc finger protein 587
chr18_+_69966725 0.380 NM_014177
C18orf55
chromosome 18 open reading frame 55
chr7_-_112545840 0.374 LOC401397
hypothetical LOC401397
chr19_+_9112052 0.373 NM_001190791
NM_020933
ZNF317

zinc finger protein 317

chr2_-_29150630 0.358 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr17_+_5264195 0.351 RPAIN
RPA interacting protein
chr14_-_81069951 0.345 NM_005065
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr18_+_54958095 0.336 NM_033280
SEC11C
SEC11 homolog C (S. cerevisiae)
chr1_+_38250953 0.332 NM_016037
UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr18_-_41938196 0.330 NM_001001937
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr5_+_137542652 0.329 KIF20A
kinesin family member 20A
chr11_+_62893836 0.320 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr19_+_61798434 0.316 NM_021216
ZNF71
zinc finger protein 71
chr12_-_61832856 0.311 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr9_+_70161634 0.306 NM_021965
PGM5
phosphoglucomutase 5
chr9_-_98656206 0.295 NM_001001662
ZNF782
zinc finger protein 782
chr19_-_41955493 0.293 NM_001193552
ZNF850
zinc finger protein 850
chr1_+_38250995 0.290 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr19_+_62885148 0.279 NM_138347
ZNF551
zinc finger protein 551
chr3_-_48516486 0.274 NM_016479
SHISA5
shisa homolog 5 (Xenopus laevis)
chr20_+_34287793 0.272 C20orf4
chromosome 20 open reading frame 4
chr7_-_132417237 0.271 NM_017812
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr16_+_23560187 0.269 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr12_+_12857516 0.266 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr11_+_2378559 0.264 TSSC4
tumor suppressing subtransferable candidate 4
chr16_+_65761905 0.263 NM_001185058
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr19_-_63018092 0.261 NM_024762
ZNF552
zinc finger protein 552
chr19_+_40900757 0.260 NM_014727
MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr19_+_39916964 0.260 ZNF181
zinc finger protein 181
chr8_+_110415725 0.259 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr1_+_32346206 0.259 NM_012316
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr16_+_73810383 0.259 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr12_+_119224506 0.257 NM_012240
SIRT4
sirtuin 4
chr2_-_86186441 0.257 POLR1A
polymerase (RNA) I polypeptide A, 194kDa
chr19_+_13090101 0.255 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr4_+_157044296 0.251 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr2_+_218843358 0.246 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr13_+_114098045 0.244 NM_001164144
NM_001164145
NM_032436
ZNF828


zinc finger protein 828


chr8_+_124154079 0.243 NM_001145088
NM_145647
WDR67

WD repeat domain 67

chr5_-_95184121 0.241 GLRX
glutaredoxin (thioltransferase)
chr3_+_171422917 0.237 PRKCI
protein kinase C, iota
chr5_+_85949511 0.235 COX7C
cytochrome c oxidase subunit VIIc
chr5_-_111120817 0.232 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr2_-_84540096 0.230 NM_003849
SUCLG1
succinate-CoA ligase, alpha subunit
chr8_+_124154117 0.228 WDR67
WD repeat domain 67
chr1_-_109420091 0.228 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr10_-_62163083 0.223 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr16_-_52295214 0.218 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr2_+_68815416 0.217 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr17_-_30724732 0.217 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr2_-_217248967 0.215 IGFBP5
insulin-like growth factor binding protein 5
chr11_+_67130898 0.211 NM_001166102
NM_007103
NDUFV1

NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa

chr8_-_145983457 0.210 NM_030580
ZNF34
zinc finger protein 34
chr20_-_32728517 0.209 PIGU
phosphatidylinositol glycan anchor biosynthesis, class U
chr19_+_42553895 0.208 NM_032453
ZNF527
zinc finger protein 527
chr6_-_159160387 0.207 EZR
ezrin
chr2_-_170138558 0.206 NM_024622
FASTKD1
FAST kinase domains 1
chr6_-_159160386 0.205 EZR
ezrin
chr6_-_159160355 0.203 EZR
ezrin
chr11_-_133628348 0.201 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
THYN1




thymocyte nuclear protein 1




chr12_-_102413875 0.201 NM_198521
NM_001099336
C12orf42

chromosome 12 open reading frame 42

chr7_-_44579787 0.199 DDX56
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
chr3_+_197951203 0.196 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr16_-_73292188 0.193 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr12_+_100795213 0.193 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr14_-_81069865 0.192 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr7_-_112545847 0.191 LOC401397
hypothetical LOC401397
chr3_+_66094324 0.190 NM_173471
SLC25A26
solute carrier family 25, member 26
chr5_+_85949518 0.187 NM_001867
COX7C
cytochrome c oxidase subunit VIIc
chr17_-_36507900 0.183 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr22_-_37232246 0.182 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_+_153317887 0.180 NM_004952
EFNA3
ephrin-A3
chr6_+_100075572 0.178 NM_001195131
LOC100130890
hypothetical protein LOC100130890
chr22_-_37232261 0.176 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr17_+_7457988 0.174 SHBG
sex hormone-binding globulin
chr10_-_98315090 0.173 TM9SF3
transmembrane 9 superfamily member 3
chr5_-_177031780 0.169 LOC202181
hypothetical LOC202181
chr10_+_21863099 0.167 NM_001195627
NM_001195628
NM_001195630
NM_004641
MLLT10



myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10




Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.64 4.83e-07 GO:0006355 regulation of transcription, DNA-dependent
4.47 8.64e-07 GO:0051252 regulation of RNA metabolic process
4.02 1.31e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.90 2.11e-06 GO:0051171 regulation of nitrogen compound metabolic process
4.19 2.34e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
4.08 3.48e-06 GO:0010556 regulation of macromolecule biosynthetic process
3.96 5.47e-06 GO:0010468 regulation of gene expression
3.80 1.04e-05 GO:0031326 regulation of cellular biosynthetic process
3.75 1.23e-05 GO:0009889 regulation of biosynthetic process
3.21 1.64e-05 GO:0080090 regulation of primary metabolic process
3.17 2.06e-05 GO:0031323 regulation of cellular metabolic process
3.20 4.77e-05 GO:0060255 regulation of macromolecule metabolic process
2.87 1.00e-04 GO:0019222 regulation of metabolic process
96.76 1.36e-02 GO:0042572 retinol metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.88 8.83e-06 GO:0043231 intracellular membrane-bounded organelle
1.88 9.09e-06 GO:0043227 membrane-bounded organelle
1.75 1.23e-05 GO:0043229 intracellular organelle
1.75 1.29e-05 GO:0043226 organelle
1.49 1.32e-03 GO:0044424 intracellular part
2.18 1.35e-03 GO:0005634 nucleus
1.46 2.70e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.41 5.85e-08 GO:0003677 DNA binding
4.74 7.25e-08 GO:0008270 zinc ion binding
4.16 5.28e-07 GO:0046914 transition metal ion binding
3.11 1.55e-05 GO:0003676 nucleic acid binding
2.63 1.97e-04 GO:0046872 metal ion binding
2.60 2.32e-04 GO:0043169 cation binding
2.60 2.40e-04 GO:0043167 ion binding